Journal
CURRENT COLORECTAL CANCER REPORTS
Volume 11, Issue 6, Pages 408-413Publisher
SPRINGER
DOI: 10.1007/s11888-015-0302-5
Keywords
Colorectal cancer; Disparities; Colonoscopy; Screening; Underserved; Ethnic minorities; Molecular biology; Genetics. Race-ethnicity
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Funding
- National Center for Advancing Translational Science [KL2TR000102-04, UL1RT000101]
- National Institute of Diabetes and Digestive and Kidney Diseases [R21DK100875]
- National Institutes of Health
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African Americans suffer the highest burden from colorectal cancer (CRC) in the USA. Studies have suggested that healthcare access and poorer utilization of preventive services may be playing more of a role in this disparity. However, African Americans also tend to develop CRC at younger ages and are more likely to have proximal cancers. This raises the possibility of higher genetic predisposition to CRC among African Americans and this has not been well studied. In this article, we reviewed possible genetic basis underpinning biological differences in CRC burden in the USA.
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