Journal
KIDNEY RESEARCH AND CLINICAL PRACTICE
Volume 34, Issue 4, Pages 194-200Publisher
KOREAN SOC NEPHROLOGY
DOI: 10.1016/j.krcp.2015.10.004
Keywords
Acute kidney injury; Cyclooxygenase Obstructive nephropathy; Prostaglandin E2; Water balance
Categories
Funding
- Danish Research Council for Health and Disease [11-107433]
- Lundbeck Foundation [R108-A10372]
- Novo Nordisk Foundation [R121-A10440]
- Karen Elise Jensen Foundation [240513-MS/ks]
- AP Moller Foundation [13-299]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning, Korea [2013R1A1A2007266, 2014R1A5A2009242]
- National Research Foundation of Korea [2013R1A1A2007266] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning of 1990s, it has been confirmed that COX exists in 2 isoforms, referred to as COX-1 and COX-2. Even though the 2 enzymes are similar in size and structure, COX-1 and COX2 are regulated by different systems and have different functional roles. This review summarizes the current data on renal expression of the 2 COX isoforms and highlights mainly the role of COX-2 and PGE2 in several physiological and pathophysiological processes in the kidney. Copyright (C) 2015. The Korean Society of Nephrology. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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