Journal
NEUROLOGY AND THERAPY
Volume 4, Issue 2, Pages 137-146Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s40120-015-0037-x
Keywords
Delayed-release dimethyl fumarate; Delphi technique; Disease management; Multiple sclerosis; Health care surveys
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Funding
- Biogen
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Introduction: Delayed-release dimethyl fumarate (DMF, also known as gastro-resistant DMF) is indicated for the treatment of patients with relapsing multiple sclerosis. Gastrointestinal (GI) adverse events (AEs) occur with DMF therapy. Methods: We used a Delphi process to reach consensus among North American clinicians on effective real-world management strategies for GI AEs associated with DMF. Clinicians were asked to complete two rounds of questionnaires developed by a steering committee; consensus in round 2 was attained if >= 70% of respondents agreed on a particular strategy. Results: Consensus was reached on several strategies to manage GI AEs, including administering DMF with food, slow titration, dose reduction, and use of symptomatic therapies. Conclusion: These consensus strategies provide clinicians with information on real-world approaches used to address the tolerability of DMF in patients with multiple sclerosis.
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