Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 169, Issue -, Pages 92-98Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.05.012
Keywords
Facile fabrication; Bowl shape; Microparticle; Oral administration; Ulcerative colitis
Funding
- National Natural Science Foundation of China [81571807, 51503172]
- Fundamental Research Funds for the Central Universities [XDJK2017B058]
- Young Core Teacher Program of the Municipal Higher Educational Institution of Chongqing
- State Key Laboratory of Silkworm Genome Biology
Ask authors/readers for more resources
Oral microparticles (MPs) have been considered as promising drug carriers in the treatment of ulcerative colitis (UC). Here, a facile strategy based on a conventional emulsion-solvent evaporation technique was used to fabricate bowl-shaped MPs (BMPs), and these MPs loaded with anti-inflammatory drug (curcumin, CUR) during the fabrication process. The physicochemical properties of the resultant BMPs were characterized by dynamic light scattering, scanning electron microscope, confocal laser scanning microscope and X-ray diffraction as well as contact angle goniometer. Results indicated that BMPs had a desirable hydrodynamic diameter (1.84 +/- 0.20 mu m), a negative zeta potential (-26.5 +/- 1.13 mV), smooth surface morphology, high CUR encapsulation efficiency and controlled drug release profile. It was found that CUR molecules were dispersed in an amorphous state within the polymeric matrixes. In addition, BMPs showed excellent hydrophilicity due to the presence of Pluronic F127 and poly(vinyl alcohol) on their surface. More importantly, orally administered BMPs could efficiently alleviate UC based on a dextran sulfate sodium-induced mouse model. These results collectively suggest that BMP can be exploited as a readily scalable oral drug delivery system for UC therapy. (C) 2018 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available