Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 170, Issue -, Pages 347-354Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.06.040
Keywords
Carbon dots; Ampicillin; Bactericidal activity; Escherichia coli; PDT
Funding
- Centre National de la Recherche Scientifique (CNRS)
- University of Lille
- Hauts-de-France region
- CPER Photonics for Society
- Agence Nationale de la Recherche (ANR)
- EU union through FLAG-ERA JTC 2015-Graphtivity
- Marie Sklodowska-Curie action (H2020-MSCA-RISE-2015) [PANG-690836]
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In the last years, carbon-based nanomaterials have attracted considerable attention in a wide range of fields, particularly in biomedicine, owing to their remarkable photo-physical and chemical properties. In this study, we demonstrate that amine-terminated carbon dots (CDs-NH2) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH2 surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH2. Therefore, the AMP immobilized onto CDs-NH2 surface together with the generation of moderate quantities of reactive oxygen species under visible light illumination are very effective to inactivate the growth of Escherichia coli.
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