Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 170, Issue -, Pages 115-121Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2018.06.003
Keywords
Selenium nanoparticles; Chitosan; Optimal synthesis conditions; Antidiabetic activity
Funding
- Sichuan Provincial Department of Education [16ZB0053]
- China Postdoctoral Science Foundation [2016M602605]
- Scientific Research Foundation of Sichuan Agricultural University [06021400]
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Chitosan-stabilized selenium nanoparticles (CTS-SeNPs) were prepared through the reduction of selenite acid with ascorbic acid. The optimal synthesis conditions of CTS-SeNPs were obtained by orthogonal experiments. Besides, the size, morphology and stability of CTS-SeNPs were characterized by transmission electron microscopy (TEM), scanning electron microscope (SEM) and dynamic light scattering (DLS). The results showed that, the CTS-SeNPs with diameter of about 54 nm could be obtained under the optimal conditions (temperature of 25 degrees C, reaction time of 2 h, Vc concentration of 0.04 M and the CTS concentration of 1.0 mg/mL). CTS-SeNPs were uniform spherical and could be stable for approximately 60 days at 4 degrees C. Further, the antidiabetic activities of CTS-SeNPs in streptozotocin (STZ)-induced diabetic mice were investigated as well. The results revealed that CTS-SeNPs at a dose of 2.0 mg Se/kg bw exhibited higher antidiabetic activity than other doses of CTS-SeNPs and other selenium compounds with the same selenium content.
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