4.7 Article

TAT-conjugated chitosan cationic micelle for nuclear-targeted drug and gene co-delivery

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 162, Issue -, Pages 326-334

Publisher

ELSEVIER
DOI: 10.1016/j.colsurfb.2017.11.066

Keywords

Chitosan; TAT; Nucleus-targeted; Cationic micelle; Co-delivery

Funding

  1. National Natural Science Foundation of China [81402563, 81571665]
  2. Training Plan for OutstandingYoung Teachersin Higher Education Institutions of Guangdong Province [YQ2015083]
  3. Dongguan Social Science and Technology Development Project [2017507152432, 2017507152433]

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We developed a high-efficiency nucleus-targeted co-delivery vector that delivers genes and drugs directly into the nucleus of cancer cells. The system is based on grafted poly-(N-3-carbobenzyloxy-lysine) (CPCL) with transactivator of transcription (TAT)-chitosan on the surface. It is designed to perform highly efficient nucleus-targeted gene and drug co-delivery. Confocal laser scanning microscopy (CLSM) revealed that more TAT-CPCL entered the nucleus than does CPCL alone. The TAT-modified vector serves as a gene and drug co-delivery mechanism to achieve high gene transfection efficiency, high apoptosis and low viability in HeLa cells. TAT-CPCL may become a vector for cancer gene treatment and a template for designing better co-deliver systems. (C) 2017 Elsevier B.V. All rights reserved.

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