Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 166, Issue -, Pages 161-169Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2018.03.018
Keywords
Photothermal therapy; Selenium nanocomposites; Drug delivery; Fluorescence imaging; Synergistic treatment
Funding
- National Natural Science Foundation of China [21176102, 21176215, 21476136, 21171035, 51472049]
- Science and Technology Commission of Shanghai Municipality [15430501200]
- Sino-German Center for Research Promotion [GZ935]
- Innovation Program of Shanghai Municipal Education Commission [14ZZ160]
- Guidance Fund of Shanghai Committee of Science and Technology [15411968800]
- Connotation Construction Project of SUES [Nhky-2015-05]
- Shanghai Municipal Education for foreign visiting scholar Program
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A multifunctional selenium nanocomposite (selenium@silica core-shell nanoshperes for loading indocyanine green(ICG)/Doxorubicin(DOX)) was fabricated to reach visible and efficient cancer treatment. The Se@SiO2-ICG nanocomposites could be used not only as excellent photothermal agents but also as carriers for DOX delivery. In addition, the Se@SiO2-ICG/DOX nanocomposites exhibited excellent fluorescence imaging and infrared imaging performance. Tumor could be effectively inhibited by Se@SiO2-ICG/DOX due to the triple treatment of photothermal effect and chemotherapy of selenium and DOX. Thus, the Se@SiO2-ICG/DOX nanocomposites have a great potential in imaging guiding synergistic treatment of cancer. (C) 2018 Elsevier B.V. All rights reserved.
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