Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 168, Issue -, Pages 2-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.04.044
Keywords
Gold nanoparticle; Lipid; Coating; Amphiphiles
Funding
- NSF [DMR-0520547]
- European Union's Horizon 2020 research and innovation programme under the SINE2020 project [654000]
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Gold nanoparticles (AuNPs) are considered suitable systems for drug delivery and diagnostics with several applications in biomedicine. Size, shape and surface functionalization of these nanoparticles are important parameters influencing their behavior in a biological environment. This study describes the preparation and the characterization of lysophosphocholine coated AuNPs by means of Small Angle Neutron Scattering (SANS), Electron Paramagnetic Resonance (EPR) and Fluorescence Spectroscopy. In particular the structure of the functionalized AuNP suspension, as well as the physical properties, of the nanoparticle organic coating are discussed. The experimental results indicated that functionalized lysophosphocholine-AuNPs form aggregates, which are composed by nanoparticles with core-shell structure. Nevertheless, the nanoparticle suspension resulted to be stable, without significant structural rearrangements even when the temperature was increased to 50 degrees C. At the same time, experimental evidences also suggested that the 18LPC layer around AuNPs presented a reduced chain packing compared to pure 18LPC aggregates. (C) 2018 Elsevier B.V. All rights reserved.
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