Journal
CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
Volume 8, Issue 4, Pages 344-352Publisher
SPRINGER
DOI: 10.1007/s12178-015-9311-x
Keywords
Chordoma; Pathophysiology; Chromosomal alterations; microRNA; DNAmethylation
Categories
Ask authors/readers for more resources
Chordoma is a rare low-grade primary malignant skeletal tumor, which is presumed to derive from notochord remnants. The pathogenesis of chordoma has not been fully elucidated. However, recent advances in the molecular biology studies have identified brachyury underlying the initiation and progression of chordoma cells. More efforts have been made on accumulating evidence of the notochordal origin of chordoma, discovering signaling pathways and identifying crucial targets in chordomagenesis. In this review, we summarize the most recent research findings and focus on the pathophysiology and molecular mechanisms of chordoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available