Journal
DATA IN BRIEF
Volume 5, Issue -, Pages 621-625Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2015.09.039
Keywords
Proteomics; Breast cancer; Bone metastasis; Secretome; Hypoxia; Pre-metastatic Niche; Lysyl Oxidase
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Funding
- Lundbeck Foundation
- Velux Foundations (VKR) [VKR 022758]
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The cancer secretome includes all of the macromolecules secreted by cells into their microenvironment. Cancer cell secretomes are significantly different to that of normal cells reflecting the changes that normal cells have undergone during their transition to malignancy. More importantly, cancer secretomes are known to be active mediators of both local and distant host cells and play an important role in the progression and dissemination of cancer. Here we have quantitatively profiled both the composition of breast cancer secretomes associated with osteotropism, and their modulation under normoxic and hypoxic conditions. We detect and quantify 162 secretome proteins across all conditions which show differential hypoxic induction and association with osteotropism. Mass Spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the dataset identifier PXD000397 and the complete proteomic, bioinformatic and biological analyses are reported in Cox et al. (2015) [1]. (C) 2015 The Authors. Published by Elsevier Inc.
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