Journal
CLINICAL RHEUMATOLOGY
Volume 37, Issue 11, Pages 3141-3150Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s10067-018-4185-0
Keywords
Bisphosphonate; Bone mineral density; Fragility fracture; Pregnancy- and lactation-associated osteoporosis
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Funding
- National Natural Science Foundation of China [81570802]
- Chinese Academy of Medical Sciences Innovative Fund for Medical Sciences (CIFMS) [2016-I2M-3-003]
- National Key Research and Development Program of China [2016YFC0901501]
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Pregnancy- and lactation-associated osteoporosis (PLO) is a rare disorder with poorly known etiology, pathophysiology, and therapy. We aimed to investigate the clinical characteristics of PLO and evaluate the effectiveness and safety of bisphosphonates on it. A total of 12 patients were diagnosed with PLO on the basis of medical history, bone mineral density (BMD), and/or fragility fractures during pregnancy and lactation. We investigated the clinical, biochemical, and radiological characteristics of patients. We assessed the effects of alendronate or zoledronic acid through observing the changes of bone turnover biomarkers and BMD during the treatment. Secondary osteoporosis was excluded by comprehensive differential diagnosis. The mean age of these patients was 31 +/- 5years old. All of these patients presented severe back pain. Multiple vertebral compression fractures (VCFs) were found in 10 patients, and the median (P25th, P75th) number of compressed vertebra was 3 (3, 5). Ten patients had vitamin D insufficiency or deficiency. Serum level of bone resorption marker (-CTX with mean of 0.68 +/- 0.41ng/ml) was moderately higher than the normal range. BMD at lumbar spine, femoral neck, and total hip were low as 0.894 +/- 0.153g/cm(2), 0.728 +/- 0.090g/cm(2), and 0.728 +/- 0.080g/cm(2), respectively. Either alendronate or zoledronic acid could effectively relieve bone pain, reduce -CTX level, and increase BMD. PLO is a rare type of osteoporosis, which was characterized by increased bone resorption and decreased BMD, even VCFs. Bisphosphonate therapy was well tolerated and effective in management of PLO, but needed to be further verified in randomized controlled trial.
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