Journal
CLINICAL ORAL IMPLANTS RESEARCH
Volume 29, Issue 6, Pages 592-602Publisher
WILEY
DOI: 10.1111/clr.13257
Keywords
bone graft; bone morphogenetic protein; canine model; compression resistant; lateral ridge augmentation
Funding
- Office of Postsecondary Education [P200A090323]
- Armed Forces Institute of Regenerative Medicine [W81XWH-14-2-0004]
- Division of Materials Research [0847711]
- National Institutes of Health [S10RR027631]
- National Science Foundation [P200A090323, W81XWH-14-2-0004, S10RR027631]
- U.S. Army
- Medical Research Acquisition Activity
- Department of Education
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0847711] Funding Source: National Science Foundation
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ObjectiveThe objective of this study was to test the hypothesis that a compression-resistant bone graft augmented with recombinant human morphogenetic protein-2 (rhBMP-2) will promote lateral ridge augmentation without the use of protective mesh in a canine model. Materials & MethodsCompression-resistant (CR) bone grafts were evaluated in a canine model of lateral ridge augmentation. Bilateral, right trapezoidal prism-shaped defects (13-14mm longx8-9mm widex3-4mm deep at the base) in 13 hounds (two defects per hound) were treated with one of four groups: (i) absorbable collagen sponge+400g rhBMP-2/ml (ACS, clinical control) protected by titanium mesh, (ii) CR without rhBMP-2 (CR, negative control), (iii) CR+200g rhBMP-2 (CR-L), or (iv) CR+400g rhBMP-2 (CR-H). All animals were euthanized after 16weeks. Ridge height and width and new bone formation were assessed by CT, histology, and histomorphometry. The release kinetics of rhBMP-2 from CR bone grafts in vitro and in vivo in a femoral condyle defect model in rabbits was also evaluated. ResultsAll four bone grafts promoted new bone formation (11-31.6 volume%) in the lateral ridge defects. For CR grafts, ridge height and width increased in a dose-responsive manner with increasing rhBMP-2 concentration. Ridge height and width measured for CR-H without the use of protective mesh was comparable to that measured for ACS with a protective mesh. ConclusionsAt the same dose of rhBMP-2, an injectable, compression-resistant bone graft resulted in a comparable volume of new bone formation with the clinical control (ACS). These findings highlight the potential of compression-resistant bone grafts without the use of protective mesh for lateral ridge augmentation.
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