Journal
FOOD CHEMISTRY
Volume 183, Issue -, Pages 235-258Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2015.03.039
Keywords
Dietary phenolic antioxidants; Synthetic phenolic antioxidants; Cancer
Funding
- FCT (Fundacao para a Ciencia e Tecnologia) [PEst-OE/SAU/UI0177/2011, Pest/C-QUI/UI0081/2011]
- FCT [SFRH/BD/44872/2008, SFRH/BD/79671/2011]
- Fundação para a Ciência e a Tecnologia [PEst-OE/SAU/UI0177/2011, SFRH/BD/44872/2008, SFRH/BD/79671/2011] Funding Source: FCT
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In this paper, a review of the literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is presented. In this overview only phenolic antioxidant compounds that display significant anticancer activity have been described. In the first part of this review, the oxidative and nitrosative stress relation with cancer are described. In the second part, the plant-derived food extracts, containing identified phenolic antioxidants, the phenolic antioxidants isolated from plants and plant-derived food or commercially available and the synthetic ones, along with the type of cancer and cells where they exert anticancer activity, are described and summarized in tables. The principal mechanisms for their anti-proliferative effects were also described. Finally, a critical analysis of the studies and directions for future research are included in the conclusion. (C) 2015 Elsevier Ltd. All rights reserved.
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