Journal
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 61, Issue 3, Pages 591-603Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0000000000000368
Keywords
postpartum depression; predictors; molecular; biomarker; risk assessment
Categories
Funding
- National Institutes of Mental Health [4T32MH093315-05, R01MH104468]
- Sage Therapeutics
- Janssen
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Postpartum depression (PPD) is one of the most frequent complications of childbirth affecting similar to 500,000 women annually (prevalence 10% to 15%). Despite the documented adverse outcomes for mother and child, there remains a great need to develop prospective approaches to identify women at risk. This review examines some of the best-characterized molecular and clinical risk factors for PPD. We illustrate that this is a growing literature but there remains a lack of reliable molecular predictors for PPD. Current best predictors are clinical assessments for psychiatric history and adverse life events, highlighting the need for increased depression screening across the perinatal period.
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