4.7 Article

MUC5AC Levels Associated With Respiratory Syncytial Virus Disease Severity

Journal

CLINICAL INFECTIOUS DISEASES
Volume 67, Issue 9, Pages 1441-1444

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy340

Keywords

respiratory syncytial virus; biomarkers; mucin; vaccine

Funding

  1. Bill and Melinda Gates Foundation [OPP1106738]
  2. Bill and Melinda Gates Foundation [OPP1106738] Funding Source: Bill and Melinda Gates Foundation

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To assess MUC5AC as a biomarker for respiratory syncytial virus (RSV) disease severity, we tested nasal aspirates from RSV+ children with mild, moderate, and severe disease. Levels were significantly higher in those in the severe and moderate groups compared to mild group, indicating MUC5AC may be a useful biomarker for RSV disease severity.

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