Journal
CLINICAL IMMUNOLOGY
Volume 196, Issue -, Pages 34-39Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2018.03.011
Keywords
Epigenetics; Biomarkers; Autoimmune diseases; SLE
Categories
Funding
- National Natural Science Foundation of China [81522038, 81602767, 81430074, 91442116, 81373195, 81771761]
- National Basic Research Program of China [2014CB541904]
- Programs of Science-Technology Commission of Hunan Province [2013F J4202]
- Natural Science Foundation of Hunan Province [2017JJ3453]
- Natural Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People's Republic of China
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Autoimmune diseases are immune system disorders in which immune cells cannot distinguish self-antigens from foreign ones. The current criteria for autoimmune disease diagnosis are based on clinical manifestations and laboratory tests. However, none of these markers shows both high sensitivity and specificity. In addition, some autoimmune diseases, for example, systemic lupus erythematosus (SLE), are highly heterogeneous and often exhibit various manifestations. On the other hand, certain autoimmune diseases, such as Sjogren's syndrome versus SLE, share similar symptoms and autoantibodies, which also causes difficulties in diagnosis. Therefore, biomarkers that have both high sensitivity and high specificity for diagnosis, reflect disease activity and predict drug response are necessary. An increasing number of publications have proposed the abnormal epigenetic modifications as biomarkers of autoimmune diseases. Therefore, this review will comprehensively summarize the epigenetic progress in the pathogenesis of autoimmune disorders and unearth potential biomarkers that might be appropriate for disease diagnosis and prediction.
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