Journal
JOURNAL OF ABNORMAL PSYCHOLOGY
Volume 124, Issue 4, Pages 890-904Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/abn0000092
Keywords
reward; bipolar disorder; social; monetary; ventral striatum
Funding
- National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Grant from the Brain & Behavior Research Foundation [20585]
- National Center for Research Resources (NCRR) [UL1 RR024139]
- National Center for Advancing Translational Science (NCATS)
- National Institutes of Health (NIH) roadmap for Medical Research
- National Institute of Drug Abuse (NIDA) [K12-DA00167]
- American Psychological Foundation/Council of Graduate Departments of Psychology (APF/COGDOP)
- Sigma Xi [G20130315163467]
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Bipolar disorder (BD) is associated with increased reactivity to rewards and heightened positive affectivity. It is less clear to what extent this heightened reward sensitivity is evident across contexts and what the associated neural mechanisms might be. The present investigation used both a monetary and social incentive delay task among adults with remitted BD Type I (n = 24) and a healthy nonpsychiatric control group (HC; n = 25) using fMRI. Both whole-brain and region-of interest analyses revealed elevated reactivity to reward receipt in the striatum, a region implicated in incentive sensitivity, in the BD group. Post hoc analyses revealed that greater striatal reactivity to reward receipt, across monetary and social reward tasks, predicted decreased self-reported positive affect when anticipating subsequent rewards in the HC but not in the BD group. Results point toward elevated striatal reactivity to reward receipt as a potential neural mechanism of persistent reward pursuit in BD.
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