Journal
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
Volume 24, Issue 1, Pages 65-72Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hmbci-2015-0042
Keywords
endocrine hormones; insulin resistance; obesity; pregnancy
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Adaptations of maternal endocrine and metabolic homeostasis are central to successful pregnancy. They insure that an adequate and continuous supply of metabolic fuels is available for the growing fetus. Healthy pregnancy is classically described as a mild diabetogenic state with significant adjustments in both insulin production and sensitivity. The placenta contributes to the endocrine adaptations to pregnancy through the synthesis of various hormones which may impact insulin action. Obesity has the highest prevalence among metabolic disease in pregnancy. This article summarizes the literature addressing the endocrine and metabolic adaptations implemented during normal pregnancy. Mechanisms of regulation are further examined in the context of maternal obesity.
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