Journal
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Volume 56, Issue 11, Pages 1828-1837Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/cclm-2017-1139
Keywords
gastric cancer; long non-coding RNAs; microRNAs; signaling pathways
Categories
Funding
- National Nature Science Foundation [81201349, 81000775]
- young medical key talents in Jiangsu province [QNRC 2016686, 2016687]
- frontier and key technical innovation projects of Nantong [MS22015049]
- Nantong Science and Technology Plan Project [MS12017008-3]
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Gastric cancer (GC) is one of the most common cancers globally. Because of the high frequency of tumor recurrence, or metastasis, after surgical resection, the prognosis of patients with GC is poor. Therefore, exploring the mechanisms underlying GC is of great importance. Recently, accumulating evidence has begun to show that dysregulated long non-coding RNAs (lncRNAs) participate in the progression of GC via several typical signaling pathways, such as the AKT and MAPK signaling pathways. Moreover, the interactions between lncRNAs and microRNAs appear to represent a novel mechanism in the pathogenesis of GC. This review provides a synopsis of the latest research relating to lncRNAs and associated signaling pathways in GC.
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