Journal
CLINICAL CARDIOLOGY
Volume 41, Issue 6, Pages 871-878Publisher
WILEY
DOI: 10.1002/clc.22951
Keywords
Cardiac Surgery; Postoperative Atrial Fibrillation; Vitamin C
Categories
Funding
- National Natural Science Foundation of China [81700602]
Ask authors/readers for more resources
We undertook a systematic review and meta-analysis to evaluate the effect of vitamin C supplementation (vitamin C solely or as adjunct to other therapy) on prevention of postoperative atrial fibrillation (POAF) in patients after cardiac surgery. PubMed, Embase, Web of Science, and Cochrane Library were systematically searched to identify randomized controlled trials assessing the effect of vitamin C supplementation in adult patients undergoing cardiac surgery, and the meta-analysis was performed with a random-effects model. Thirteen trials involving 1956 patients were included. Pooling estimate showed a significantly reduced incidence of POAF (relative risk [RR]: 0.68, 95% confidence interval [CI]: 0.54 to 0.87, P=0.002) both in vitamin C alone (RR: 0.75, 95% CI: 0.63 to 0.90, P=0.002) and as an adjunct to other therapy (RR: 0.32, 95% CI: 0.20 to 0.53, P<0.001). The results remain stable and robust in subgroup and sensitivity analyses, and trial sequential analysis also confirmed that the evidence was sufficient and conclusive. Additionally, vitamin C could significantly decrease intensive care unit length of stay (weighted mean difference: -0.24days, 95% CI: -0.45 to -0.03, P=0.023), hospital length of stay (weighted mean difference: -0.95days, 95% CI: -1.64 to -0.26, P=0.007), and risk of adverse events (RR: 0.45, 95% CI: 0.21 to 0.96, P=0.039). Use of vitamin C alone and as adjunct to other therapy can prevent POAF in patients undergoing cardiac surgery and should be recommended for patients receiving cardiac surgery for prevention of POAF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available