Journal
CLINICAL CANCER RESEARCH
Volume 24, Issue 15, Pages 3560-3571Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-17-3862
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Funding
- Science and Technology Development Fund (FDCT) of Macao SAR [FDCT 025/2014/A1, FDCT 088/2014/A2]
- Multi-Year Research Grant from the University of Macau [MYRG2015-00037-FHS, MYRG2015-00167-FHS, MYRG2016-00251-FHS]
- National Natural Science Foundation of China [81772980, 31701153]
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Purpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important for the clinical outcome. To elucidate the mechanistic relationship between immune repertoire and cancer genotype in ovarian cancer, the development of a well-defined immune score for ovarian cancer is required. Experimental Design: From a collection of 2,203 patient samples of advanced ovarian cancer from public available resources, we evaluated the prognostic values for a compendium of immune marker genes and proposed an immune score. The relationships between immune score, tumor-infiltrating immune cells, cancer genotypes, and their impact on patient outcome were characterized. Results: Loss of chemokine and IFNg pathway genes is frequent in ovarian cancer and is significantly associated with low immune score and poor outcome. Chemotherapy can increase the immune score of tumors by inducing the expression of IFNg inducible chemokines. High immune score is significantly associated with BRCA1/2 mutation status and the response to chemotherapy. Multivariate analysis revealed that immune score is a strong predictor of patient survival and the response to immunotherapy. Conclusions: Our results reveal the drivers of the immune repertoire of advanced ovarian cancer and demonstrate the importance of immune score as an independent prognostic signature and a potent indicator of intratumoral immune status. (C) 2018 AACR.
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