4.7 Article

Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury

Journal

CLINICAL CANCER RESEARCH
Volume 24, Issue 7, Pages 1516-1517

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AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-17-3276

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Extracellular vesicles containing glycogen phosphorylase, brain/ heart (PYGB) have been demonstrated as a sensitive biomarker for normal cardiac injuries for patients after chemotherapy. Oxidative stress was suggested to be the mechanism behind the chemotherapy-induced tissue damage and augmented with mitochondrial antioxidant could be an effective means of early intervention. (C) 2018 AACR.

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