Journal
FOOD CHEMISTRY
Volume 174, Issue -, Pages 597-605Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.11.067
Keywords
Fluoroquinolones; Sulphonamides; Metabolites; Multiresidue analysis; Ultra-high performance liquid chromatography; Mass spectrometry; Bovine milk
Funding
- Natural Science Found of Hebei Province [B2008000583]
- Plan of Science and Technology of Hebei Province of China [10967126D]
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A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 mu g kg(-1) for FQs and 0.13-1.68 mu g kg(-1) for SAs. Mean recoveries ranging from 61% to 115% were achieved at spiked level of 0.5-100 mu g kg(-1). The intra- and inter-day precisions were in the range of 6.3-10.7% and 9.0-13.4%, respectively. This novel approach has high speed and sensitivity, and can ensure the multiclass and multiresidue analysis of bovine milk at low mu g kg(-1) level. The content of each analyte residue is much lower than the maximum residue limits. Some residues in milk were confirmed in according to the Commission Decision 657/2002/EC. (C) 2014 Elsevier Ltd. All rights reserved.
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