Journal
CLINICAL AND EXPERIMENTAL ALLERGY
Volume 48, Issue 7, Pages 773-786Publisher
WILEY
DOI: 10.1111/cea.13178
Keywords
Asthma; Allergens; Air pollution; Particulate matter; Airway epithelium; Epithelial cytokines
Categories
Funding
- Interuniversity Attraction Poles Programme (IUAP)-Belgian state-Belgian Science Policy
- Fund for Scientific Research-Flanders (FWO-Vlaanderen [G0G2318N]
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Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses. We describe the available literature on the topic including invitro studies, findings in humans (ie observations in human cohorts, human controlled exposure and exvivo studies) and invivo animal studies. In brief, it has been shown that exposure to PM modulates the airway epithelium and promotes the production of several cytokines, including IL-1, IL-6, IL-8, IL-25, IL-33, TNF-, TSLP and GM-CSF. Further, we propose that PM-induced type 2-promoting cytokines are important mediators in the acute and aggravating effects of PM on airway inflammation. Targeting these cytokines could therefore be a new approach in the treatment of asthma.
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