Journal
CLINICA CHIMICA ACTA
Volume 476, Issue -, Pages 160-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2017.11.031
Keywords
Afamin; Pregnancy complications; Pre-eclampsia; Gestational diabetes mellitus
Categories
Funding
- Austrian Science Fund [P19969-B11]
- Austrian Science Fund (FWF) [P19969] Funding Source: Austrian Science Fund (FWF)
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Objective: Aim of this study was to assess the prognostic capability of afamin to predict pregnancy complications. Method: First-trimester screening was consecutively performed in 4948 pregnant women, of whom 474 women developed pregnancy complications [gestational hypertension (n = 84), pre-eclampsia (n = 30), intrauterine growth restriction (n = 107), preterm birth (n = 44), and gestational diabetes mellitus (n = 209)]. To each woman with pregnancy complications an uncomplicated pregnancy was matched for body mass index. Afamin serum concentrations were measured in 948 pregnant women at the first-trimester screening. Results: Median afamin concentrations were significantly higher in women developing pre-eclampsia or gestational diabetes mellitus when compared to women with uncomplicated pregnancies (76 mg/L vs. 65 mg/L, p = 0.001 and 80 mg/L vs. 69 mg/L, p < 0.001). There was no difference in median afamin values between all other pregnancy complications and their matched controls. Increased afamin (i.e. > 65 mg/L) was a strong and independent predictor for the development of pre-eclampsia (risk ratio, 24.58; 95%CI, 2.82-214.12; p = 0.004) as well as gestational diabetes mellitus (risk ratio, 2.07; 95%CI, 1.33-3.22; p = 0.001). Conclusion: In this large nested case-control study increased afamin concentrations were a strong and independent predictor for pre-eclampsia and gestational diabetes mellitus, suggesting a potential role of afamin as predictive marker for pregnancy-related metabolic disorders.
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