Journal
CHEMICKE LISTY
Volume 109, Issue 10, Pages 748-754Publisher
CHEMICKE LISTY
Keywords
pharmaceutical research; original drug; deuterated drug; deuterated nutraceuticals; kinetic isotope effect; metabolisms; clinical studies
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The article's aim is to describe to the general chemical audience how results of metabolic studies together with application of kinetic isotope effect of deuterated analogs can lead to a new class of drugs - deuterated drugs. The fact is illustrated by several case studies of deuterated analogs of well-known drugs which are currently under development.
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