Journal
CIRCULATION
Volume 137, Issue 18, Pages 1949-1964Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.117.030693
Keywords
hemorrhage; magnetic resonance imaging; percutaneous coronary intervention; ST elevation myocardial infarction
Funding
- British Heart Foundation [FS/10/039/28270]
- National Institute for Health Research University College London Hospitals Biomedical Research Center, Duke-National University Singapore Medical School
- Singapore Ministry of Health's National Medical Research Council under its Clinician Scientist-Senior Investigator scheme [NMRC/CSA-SI/0011/2017]
- Singapore Ministry of Education Academic Research Fund [MOE2016-T2-2-021]
- EU-CARDIOPROTECTION Cooperation in Science and Technology Action [CA16225]
- Intramural Research Program of the National Heart, Lung, and Blood Institute, National Institutes of Health
- National Heart, Lung, and Blood Institute, National Institutes of Health [R01 HL136578, R01 HL133407]
- British Heart Foundation Center of Research Excellence Award [RE/13/5/30177]
- BHF grants [FS/15/54/31639, PG/11/2/28474, PG/14/64/31043]
- Medical Research Scotland
- Chief Scientist Office
- Scottish Funding Council
- [NMRC/CGAug16C006]
- EPSRC [EP/N014642/1] Funding Source: UKRI
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Although mortality after ST-segment elevation myocardial infarction (Ml) is on the decline, the number of patients developing heart failure as a result of MI is on the rise. Apart from timely reperfusion by primary percutaneous coronary intervention, there is currently no established therapy for reducing MI size. Thus, new cardioprotective therapies are required to improve clinical outcomes after ST-segment- elevation MI. Cardiovascular magnetic resonance has emerged as an important imaging modality for assessing the efficacy of novel therapies for reducing MI size and preventing subsequent adverse left ventricular remodeling. The recent availability of multiparametric mapping cardiovascular magnetic resonance imaging has provided new insights into the pathophysiology underlying myocardial edema, microvascular obstruction, intramyocardial hemorrhage, and changes in the remote myocardial interstitial space after ST-segment-elevation MI. In this article, we provide an overview of the recent advances in cardiovascular magnetic resonance imaging in reperfused patients with ST-segment-elevation MI, discuss the controversies surrounding its use, and explore future applications of cardiovascular magnetic resonance in this setting.
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