Journal
FOOD CHEMISTRY
Volume 174, Issue -, Pages 270-278Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.11.056
Keywords
beta-Carotene microemulsion; Phase diagrams; Medium-chain fatty acids; Monoglycerides; Non-ionic surfactant; Cytotoxicity test
Funding
- New Zealand Ministry of Business, Innovation, and Employment (MBIE) under New Zealand-Korea Research collaboration for Food Innovation [19184]
- University of Otago
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The impact of oil type and fatty acid chain length on the development of food-grade microemulsions for the entrapment of beta-carotene was investigated. The microemulsion region of a ternary phase diagram containing short chain monoglycerides was larger than for di- and triglycerides when Tween 80 was used as surfactant. The cytotoxicity of microemulsions composed of a 30% monoglyceride oil, 20% Tween 80 and 50% aqueous buffer were evaluated using an in vitro cell culture model (human epithelial colorectal adenocarcinoma, Caco-2). The cytotoxicity test showed that the viability of Caco-2 cells against beta-carotene microemulsions at concentrations of 0.03125% (v/v) was higher than 90%. This study suggests that short chain monoglycerides could be used with Tween 80 to prepare transparent beta-carotene-encapsulated O/W microemulsions in the particle size range of 12-100 nm. (C) 2014 Elsevier Ltd. All rights reserved.
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