Journal
CHIRALITY
Volume 30, Issue 5, Pages 609-618Publisher
WILEY
DOI: 10.1002/chir.22833
Keywords
analysis; chiral drug; mass spectrometry; stereoisomers
Funding
- National Natural Science Foundation of China [81230080]
- National Key Project of China [2017YFC0908600]
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Chiral molecules are of great importance in the life science since individual enantiomers may differ in biological activity, mechanism, and toxicity, making it necessary to explore efficient chiral analysis methods. Chromatography approaches are often used to differentiate enantiomers while mass spectrometry (MS) was thought to be blind in chiral analysis. With the development of MS technique, it began to play a more and more crucial part in chiral observation. In this review, we will give a detailed introduction of the analysis methods related to MS for chiral drugs, including its mechanism, applications, and future development.
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