Journal
CHIRALITY
Volume 30, Issue 5, Pages 602-608Publisher
WILEY
DOI: 10.1002/chir.22838
Keywords
circular dichroism; circularly polarized luminescence; helical structures; modified RNA; DNA; pyrene
Funding
- JSPS KAKENHI [17K05886]
- Grants-in-Aid for Scientific Research [17K05886, 15H03884] Funding Source: KAKEN
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In this report, we describe the circularly polarized luminescence (CPL) of the RNA duplexes having one to four 2-O-pyrene modified uridines (Upy) and the DNA duplexes having two, four, and six pyrene modified non-nucleosidic linkers (Py). Both the pyrene -stack arrays formed on the RNA and DNA double helical structures exhibited pyrene excimer fluorescence. In the pyrene-modified RNA systems, the RNA duplex having four Upys gives CPL emission with g(lum) value of <0.01 at 480nm. The structure of pyrene stacks on the RNA duplex may be rigidly regulated with increase in the Upy domains, which resulted in the CPL emission. In the DNA systems, the pyrene-modified duplexes containing two and four Pys exhibited CPL emission with g(lum) values of <0.001 at 505nm. The pyrene -stack arrays presented here show CPL emission. However, the g(lum) values are relatively small when compared with our previous system consisting of the pyrene-zipper arrays on RNA.
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