4.6 Article

Effect of Rapid Eye Movement Sleep Behavior Disorder on Obstructive Sleep Apnea Severity and Cognition of Parkinson's Disease Patients

Journal

CHINESE MEDICAL JOURNAL
Volume 131, Issue 8, Pages 899-906

Publisher

WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0366-6999.229888

Keywords

Cognitive Dysfunction; Sleep Apnea; Obstructive; Parkinson's Disease; Rapid Eye Movement Sleep Behavior Disorder

Funding

  1. National Key R AMP
  2. D Program of China [2017YFC0909100]
  3. National Natural Science Foundation of China [91649114]
  4. Jiangsu Provincial Social Development Projects [BE2017653]
  5. Jiangsu Provincial Medical Key Discipline Project [ZDXKB2016022]
  6. Jiangsu Key Laboratory of Neuropsychiatric Diseases [BM2013003]
  7. Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
  8. Suzhou Science and Technology Development Program [SYS201624]
  9. Suzhou Youth Technology Project Foundation [KJXW2016014]
  10. Priority Academic Program Development of Jiangsu Higher Education Institutions

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Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG). We collected clinical data, PSG results, and compared information between patients with and without RBD or OSA by analysis of covariance. We also investigated the effect of these sleep disorders on cognitive impairment using linear regression. Results: We grouped participants as follows: PD only (n = 53), PD + OSA (n = 29), PD + RBD (n = 61), and PD + RBD OSA (n = 31). Minimum oxygen saturation (SaO(2)) during whole sleep and in REM sleep was higher in PD + RBD + OSA patients than that in PD + OSA patients. PD + RBD patients had worse Mini-Mental Status Examination and Montreal Cognitive Assessment (MoCA) scores than those in the PD group (P < 0.001), especially in visuospatial/executive, attention, and memory functions. The PD + OSA group performed worse than the PD group in the delayed recall domain. After adjusting for age, sex, body mass index, education, disease severity, and other sleep disorders, MoCA was negatively associated with OSA (beta = -0.736, P = 0.043) and RBD (beta = - 2.575, P < 0.001). The severity of RBD (tonic/phasic electromyography activity) and OSA (apnea-hypopnea index/oxygen desaturation index/minimum SaO(2)) were also associated with MoCA. The adjusted beta values of RBD-related parameters were higher than that for OSA. Conclusions: We found that RBD alleviated OSA severity; however, RBD and OSA together exacerbated PD cognitive impairment. Further studies are needed to evaluate whether OSA treatment can improve cognition in PD.

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