Construction of Chiral Cyclic Compounds via Asymmetric Cascade [1,n]-Hydride Transfer/Cyclization

The C(sp(3))-H adjacent to heteroatoms can be readily functionalized to C-C, C-N, C-O bonds etc. via cascade [1,n]-hydride transfer/cyclization, which shows high potency to construct 5-membered, 6-membered and all carbon rings. This intriguing cascade process can be employed to synthesize common skeletons of significant natural products and pharmaceutical molecules. Chiral amines, Lewis acids and Bronsted acids have been successfully utilized to catalyze the asymmetric cascade reaction.