Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 38, Issue 4, Pages 919-925Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc201711016
Keywords
diosgenin; derivative; antitumor activity; amide
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Funding
- National Natural Science Foundation of China [21602083]
- Southwest University for Nationalities Graduate Student Innovative Project [CX2016SZ045]
- Sichuan Provincial Department of Education Research Project [15ZB0487]
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Nine novel diosgenin derivatives were designed and synthesized by using diosgenin as a precursor. Their structures were identified by H-1 NMR, C-13 NMR, IR and FIRMS. Antitumor activity (A549, A431, H1975, HCT-116, Aspc-1, Ramos) and cytotoxicity (HBE, LO-2) were measured for all derivatives using thiazolyl blue tetrazolium bromide (MTT). The results show that most diosgenin derivatives have significant anti-tumor activity and low cytotoxicity.
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