Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 36, Issue 9, Pages 875-885Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201800173
Keywords
DNA origami nanopore; single molecule detection; nanopore fabrication
Categories
Funding
- National Natural Science Foundation of China [21605124, 21605122]
- Natural Science Foundation of Shaanxi Province [2016JQ2014]
- Special Research Plan for the Education Department of Shaanxi province [16JK1767]
- Foundation of Key Laboratory of Modern Separation Science in Shaanxi Province [2010JS104, 11JS098]
- Foundation of Science and Technology in Shaanxi Province [2013SZS18-Z01]
- Top-rated Discipline construction scheme of Shaanxi higher education and Tang Scholar
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In recent years, bio-nanopore and solid-state nanopore have been greatly improved for molecule bio-sensing. Whereas, the development of this scientific field seems to have encountered a bottleneck due to their respective limitations. The small pore size of the former impedes the detection of large single molecule, and the latter is difficult to achieve similar accuracy and functional control. DNA origami plays a novel role to bring more opportunities for the development of nanopore technology since it is relatively easy to synthesize and modify. This review mainly focuses on introducing the DNA origami nanopore fabrication methods, characterization and application. Meanwhile, the challenges in the present DNA origami nanopore research are also discussed.
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