Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 36, Issue 9, Pages 851-856Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201800129
Keywords
aryl ketone; asymmetric; f-Amphamide; hydrogenation; iridium
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Funding
- Southern University of Science and Technology
- Shenzhen Science and Technology Innovation Committee [KQTD201507-17103157174]
- National Natural Science Foundation of China [21573102]
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A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide (f-Amphamide) ligands have been developed and applied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results (up to >99% conversion, >99% ee and TON up to 200 000). DFT calculations suggest an activating model involving an alkali cation Li+.
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