Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 80, Issue -, Pages 271-276Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2015.03.021
Keywords
Maillard reaction products; Toxicity; Acute oral toxicity; Sub-chronic toxicity
Categories
Funding
- National Natural Science Foundation of China [31101328]
- Natural Science Foundation of Hainan Province [311063]
- Chinese Academy of Tropical Agricultural Sciences [1630052012005, 1630052014005]
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Maillard reaction products (MRPs) derived from glucose-cysteine reactions have excellent anti-browning ability. However, there is a lack of information about their acute and sub-chronic toxicities. To our knowledge, the present study is the first to evaluate the acute and sub-chronic toxicities of MRPs in experimental animals. Acute toxicity testing and analysis by Horn's method showed that the median lethal oral dose (LD50) of MRPs in rats was 6.81 g/kg body weight. The sub-chronic toxicity test involved feeding rats with diet containing 0, 0.43, 0.85, or 1.70% (w/w) MRPs for 90 days. These treatments did not affect mortality, gross pathology, histology, hematology, or blood chemistry, and there were no dose-dependent changes in feed consumption. Based on these results, the dietary no-observed-adverse-effect level (NOAEL) for 90-day exposure was 1.29 and 1.51 g MRPs/kg body weight/day for male and female rats, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
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