Journal
CHINESE CHEMICAL LETTERS
Volume 29, Issue 11, Pages 1637-1640Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.06.003
Keywords
HIV RNA; Dinuclear metallic ligands; Binding; Molecular recognition; Selectivity
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Funding
- National Key R&D Program of China [2017YFA0208100]
- National Natural Science Foundation of China [21778057, 21502201, 21420102003]
- Beijing Natural Science Foundation [2162049]
- Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
- Chinese Academy of Sciences
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We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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