4.7 Article

Synthesis of 9-phenol-substituted xanthenes by cascade O-insertion/1,6-conjugate addition of benzyne with ortho-hydroxyphenyl substituted para-quinone methides

Journal

CHINESE CHEMICAL LETTERS
Volume 30, Issue 2, Pages 386-388

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.04.003

Keywords

Benzyne; para-Quinone methides; Xanthene; Cascade reaction; Cycloaddition

Funding

  1. National Natural Science Foundation of China [21462034]
  2. Young Scientists Foundation of Shihezi University [RCZX201546, 2015ZRKXJQ05]
  3. Excellent Young Teachers Plan of Bingtuan [CZ027203]

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The cascade O-insertion/1,6 conjugate addition between benzynes and ortho-hydroxyphenyl substituted para-quinone methides has been reported, affording 9-phenol substituted xanthenes in 49%-84% yields. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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