Journal
CHINESE CHEMICAL LETTERS
Volume 29, Issue 10, Pages 1436-1444Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.12.020
Keywords
Metal nanoclusters; Fluorescent probes; Cellular imaging; In vivo; Near-infrared
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Funding
- National Natural Science Foundation of China (NSFC) [21705129]
- Program of Introducing Talents of Discipline to Universities [B08040]
- National 1000 Young Talent Program
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Fluorescent metal nanoclusters (MNCs) have recently emerged as a novel kind of promising fluorescent probes for biological imaging because of their ultrasmall core size (<2 nm), strong photoluminescence facile availability and good biocompatibility. In this review, we provide an update on recent advances in the development of near infrared (NIR)-emitting MNCs in terms of synthesis strategies and bioimaging applications. We mainly focus on the utilization of NIR-emitting MNCs (including Au, Ag, Cu and alloy NCs) either as single modal imaging (fluorescence intensity-based imaging, fluorescence lifetime imaging, two-photon imaging) probes or as multimodal imaging (such as NIR fluorescence/X-ray computed tomography/magnetic resonance imaging, NIR fluorescence/photoacoustic imaging/magnetic resonance imaging, NIR fluorescence/single photon emission computed tomography) probes in biological cells and tissues. Finally, we give a brief outlook on the future challenges and prospects of developing NIR-emitting MNCs for bioimaging. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences Published by Elsevier B.V. All rights reserved,
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