Journal
CHEMSUSCHEM
Volume 11, Issue 3, Pages 532-535Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201702356
Keywords
alkaloids; biomass; cancer; shell biorefinery; sustainable synthesis
Funding
- New Zealand Ministry of Business, Innovation and Employment (MBIE)
- National University of Singapore [WBS R-279-000-464-133]
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A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicinA has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.
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