Journal
FIBERS
Volume 3, Issue 4, Pages 478-490Publisher
MDPI
DOI: 10.3390/fib3040478
Keywords
biodegradable nanofiber; poly(epsilon-caprolactone); imiquimod; anti-cancer fiber
Categories
Funding
- Australian Government's New Colombo Plan Program
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [25702029]
- Grants-in-Aid for Scientific Research [25702029] Funding Source: KAKEN
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In this paper we investigate a potential new treatment option for basal cell carcinoma using electrospun polymer nanofibers. Poly(epsilon-caprolactone) fibers incorporated with the anti-cancer drug imiquimod were successfully produced for the first time. These fibers were characterized and their diffusion release profile tested in vitro. A range of different electrospinning parameters were investigated in order to determine the most effective approach in optimizing the fibers for future in vivo testing. Characterization showed stable and homogeneous distribution of imiquimod. Although the drug was released faster than what would be needed to replicate the current treatment model, this system would ideally allow for a treatment option which reduces side effects and is more convenient for the patient than the current topical treatment.
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