Journal
CHEMOSPHERE
Volume 200, Issue -, Pages 358-365Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.02.080
Keywords
Iranian heavy crude oil; Caenorhabditis elegans; Transgenerational effects; Differential exposure; Histone methylation
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Funding
- Mid-career Researcher Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017R1A2B3002242]
- Mid-career Researcher Program through the Taean Environmental Health Center operating grant for the Investigation of Long-term Health Effects of the Hebei Spirit Oil Spill - Ministry of Environment of Korea
- NIH Office of Research Infrastructure Programs [P40 OD010440]
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As part of a study to explore the long-term effects of the Hebei Spirit oil spill accident, transgenerational toxicity and associated epigenetic changes were investigated in the nematode Caenorhabditis elegans. Under experimental conditions, worms were exposed to Iranian heavy crude oil (IHC) under three different scenarios: partial early-life exposure (PE), partial late-life exposure (PL), and whole-life exposure (WE). Growth, reproduction, and histone methylation were monitored in the exposed parental worms (PO) and in three consecutive unexposed offspring generations (F1-3). Reproductive potential in the exposed PO generation in the WE treatment group was reduced; additionally, it was inhibited in the unexposed offspring generations of the PO worms. This suggests that there was transgenerational inheritance of defective reproduction. Comparison of developmental periods of exposure showed that IHC-treated worms in the PL group had a greater reduction in reproductive capacity than those in the PE group. Decreased methylation of histone H3 (H3K9) was found in the IHC-exposed parental generation. A heritable reduction in reproductive capacity occurred in wildtype N2 but was not found in a H3K9 histone methyltransferase (HMT) mutant, met-2(n4256), suggesting a potential role for HMT in trans generational toxicity. Our results suggest that the reproductive toxicity after IHC exposure could be heritable and that histone methylation is associated with the transmission of the inherited phenotype. (C) 2018 Elsevier Ltd. All rights reserved.
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