Journal
CHEMMEDCHEM
Volume 13, Issue 15, Pages 1490-1507Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800253
Keywords
1H-indazoles; 2H-indazoles; anticancer agents; kinase inhibitors
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Funding
- Hong Kong Scholar Program [XJ2015032]
- National Natural Science Foundation of China [21602132]
- Shanghai Science and Technology Innovation Program [15431900700]
- Shanghai Natural Science Fund [16ZR1418100]
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Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts have been made to seek new active drugs with improved anticancer efficacy. Indazole-containing derivatives are endowed with a broad range of biological properties, including anti-inflammatory, antimicrobial, anti-HIV, antihypertensive, and anticancer activities. In recent years, the development of anticancer drugs has given rise to a wide range of indazole derivatives, some of which exhibit outstanding activity against various tumor types. The aim of this review is to outline recent developments concerning the anticancer activity of indazole derivatives, as well as to summarize the design strategies and structure-activity relationships of these compounds.
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