Journal
CHEMMEDCHEM
Volume 13, Issue 10, Pages 1018-1027Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800073
Keywords
antibacterial agents; antibiotics; bile acids; polyamines; steroids
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Funding
- Virbac SA
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The emergence of multidrug-resistant bacteria and pathogens has created an urgent need for the development of new antibiotics. Herein we report our investigations into the broad-spectrum activity of an easily prepared water-soluble polyaminosterol compound, namely claramineA1, against both drug-sensitive and drug-resistant Gram-negative and Gram-positive bacterial strains. We also report its peculiar mechanism of action, which differs from that of all the other well-known classes of antibiotics, toward Gram-negative and Gram-positive bacteria. Given their low cytotoxicity, this class of compounds based on claramineA1 could constitute an effective response to combat the emergence of multidrug-resistant bacteria and nosocomial diseases.
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