Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 13, Issue 17, Pages 2559-2565Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201800759
Keywords
amino alcohols; hydrogenation; lactams; pincer complexes; ruthenium
Categories
Funding
- National Key R&D Program of China [2016YFA0202902]
- National Natural Science Foundation of China [21572036, 21861132002]
- Department of Chemistry, Fudan University
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By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.
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