Journal
EUROPEAN JOURNAL OF DERMATOLOGY
Volume 25, Issue 5, Pages 384-391Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2015.2544
Keywords
dermatopharmacology; retinoid therapy; retinoids; Vtamin A derivatives
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Retinoids (vitamin A and its metabolites) are potent natural regulators of cellular activities, including cell growth and differentiation, and they mediate many essential regulatory functions, especially in the skin. Biologically active retinoids exert their effects by binding to nuclear retinoic acid receptors and retinoid-X-receptors. The group of pharmacologically used retinoids include naturally occurring and chemically synthesised vitamin A derivatives. Due to their influence on keratinocyte proliferation, epidermal differentiation and keratinisation, retinoids are commonly used in the field of. dermatopharmacology. For safe administration of retinoids, in-depth information about adverse effects and comprehensive information of the patient are important. This article gives an overview on the effects, use, and side-effects of topical and systemic retinoids in dermatology.
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