Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 52, Pages 13947-13953Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201803064
Keywords
lactones; macrocycles; macrolides; medium-sized rings; ring expansion
Categories
Funding
- Leverhulme Trust [ECF-2015-013]
- University of York
- EPSRC [EP/P029795/1, EP/N509802/1]
- EPSRC [EP/P029795/1] Funding Source: UKRI
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Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise sequences of hydroxy- and amino acids can be assembled in high yields by growing them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks.
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