Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 38, Pages 9463-9476Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800853
Keywords
diabetes; fatty acids; insulin resistance; saturated lipids; synthetic methods
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After a brief overview of the biological significance of FAHFAs, the present Minireview highlights the different strategies developed for their chemical syntheses. The term FAHFAs has been introduced in 2014 for fatty acyl esters of hydroxyl fatty acids, found in adipocytes, with antidiabetic properties. However, many other natural products contain this type of branched lipids in their structure. This review was then extended to the synthesis of these subunits, even though the length of the lipid chains and the location of the ester linkages are different, since the developed strategies may be applied to the synthesis of FAHFA.
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