Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 56, Pages 14854-14863Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201802873
Keywords
deep eutectic solvents; organometallic chemistry; solvent effects; sustainable chemistry; water
Categories
Funding
- University of Bari [Perna01333214Ricat, Capriati005057Prin15]
- Interuniversity Consortium C.I.N.M.P.I.S. [COCM8470P0]
- EPSRC [EP/N011384/1]
- MINECO of Spain [CTQ2014-51912-REDC, CTQ2016-75986-P]
- Gobierno del Principado de Asturias [GRUPIN14-006]
- Fundacion BBVA
- EPSRC [EP/N011384/1] Funding Source: UKRI
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There is a strong imperative to reduce the release of volatile organic compounds (VOCs) into the environment, and many efforts are currently being made to replace conventional hazardous VOCs in favour of safe, green and bio-renewable reaction media that are not based on crude petroleum. Recent ground-breaking studies from a few laboratories worldwide have shown that both Grignard and (functionalised) organolithium reagents, traditionally handled under strict exclusion of air and humidity and in anhydrous VOCs, can smoothly promote both nucleophilic additions to unsaturated substrates and nucleophilic substitutions in water and other bio-based solvents (glycerol, deep eutectic solvents), competitively with protonolysis, at room temperature and under air. The chemistry of polar organometallics in the above protic media is a complex phenomenon influenced by several factors, and understanding its foundational character is stimulating in the perspective of the development of a sustainable organometallic chemistry.
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